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Xiongpeng Zhu on Muck Rack

Xiongpeng Zhu

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Hedgehog/GLI1 regulates EMT and cancer stem cell properties via the GLI1-Bmi1 axis in diffuse large B-cell lymphoma

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By Huifang Xiao, Chuntuan Li, Jingjing Gao, Wenqian Xu, Pengliang Xin, Xiongpeng Zhu
| Nature Verified
Abstract R-CHOP-treated diffuse large B-cell lymphoma (DLBCL) shows heterogeneous outcomes. High-risk relapsed/refractory (R/R) patients, especially activated B-cell (ABC) and double-/triple-hit subtypes, have poor prognosis, highlighting an urgent need to uncover the underlying aggressive molecular mechanisms. Epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties drive its invasion, metastasis, and drug resistance.
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