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Xiu-Juan Yang

As seen in: MDPI, Cell Metabolism
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Articles

Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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By Systematic Diseases, Shuo Xu, Ting Dong, Hao-Nan Zhou, Hui Li, Xiu-Juan Yang, Zhi-jun Wang, Qi Luo, Jun-Hao Yin, Xin-Yi Ma, Yi-Ping Pu, Li-Song Xie, Yan-Xiong Shao, Zi-Rui Zong, Xin-Di We
| Cell Metabolism Verified
Highlights • KAT6A deficiency in CD4+ T cells dampens the CD4+ T cell response in autoimmunity • KAT6A supports glucose metabolism and subsequent CD4+ T cell responses • KAT6A epigenetically programs the transcriptional activity of several glycolytic genes • Inhibition of KAT6A shows promising therapeutic potential for autoimmune diseases Summary Augmented CD4+ T cell response in autoimmunity is characterized by extensive metabolic reprogramming.
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