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Xiufei Tang

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Articles

Structural insights into ligand recognition and activation of the human oxoglutarate receptor OXGR1

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By Tingshuai Ma, Ziyan Chen, Ximin Chi, Quanchang Gu, Qiang Su, Enyuan Liang, Xiufei Tang
| Nature Verified
Abstract The human oxoglutarate receptor 1 (OXGR1/GPR99) is a G protein–coupled receptor (GPCR) expressed in the kidney that senses metabolic signals. In addition, OXGR1 also responds to immunometabolites in the airway epithelium and contributes to innate airway defense. Despite the identification of endogenous ligands α-ketoglutarate (α-KG) and itaconate (ITN), the molecular basis of these metabolite recognition and activation remains poorly understood.
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