Xiulan Lai

Sensitive analysis for RC and alternative intervention scenarios We use Latin Hypercube Sampling method to analyze the sensitivity of parameter on the reproduction number; the results of the sensitive analysis for year 2005, 2010 and 2015 are shown in Fig 6. The ranges of parameter values used for sensitive analysis are shown in Table 5. Fig 6. Estimated annual value of the reproduction number RC and its sensitivity analysis. (A) The estimated value of RC from 2005 to 2020.

Loading metrics Open Access Peer-reviewed Research Article Xiulan Lai, Wenrui Hao, Avner Friedman Xiulan Lai, Wenrui Hao, Avner Friedman Published: April 20, 2020 https://doi.org/10.1371/journal.pone.0231499 Figures Abstract Drug resistance is a primary obstacle in cancer treatment. In many patients who at first respond well to treatment, relapse occurs later on. Various mechanisms have been explored to explain drug resistance in specific cancers and for specific drugs.

BMC Systems Biology201913:30 https://doi.org/10.1186/s12918-019-0706-y ©  The Author(s) 2019 Received: 26 January 2018 Accepted: 19 February 2019 Published: 13 March 2019 Abstract Background One of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may interfere with the effectiveness of the other agent.