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Xiuying Duan

As seen in: Nature, Science Magazine
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Articles

Frontotemporal dementia associated CHCHD10 V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex

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By Jie Sheng, Jing Yan, Yan Xu, Xingyu Xu, Xuemei Zhang, Anqi Wang, Buhui Liu, Jun Ma, Xiuying Duan, Heng Zhou, Wei Liu
| Nature Verified
Abstract Frontotemporal dementia (FTD), a neurodegenerative disorder characterized by early-onset cognitive decline, includes two major pathologic types: FTD-Tau and FTD-TDP. Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) encodes a mitochondrial protein, and the CHCHD10V57E variant is a novel mutation clinically identified in FTD patients. The role of CHCHD10 mutants in the pathogenesis of FTD-TDP has been largely reported.
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Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis

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By Jia Zhou, Wei Liu, Lingna Xu, Xiuying Duan
| Science Magazine Verified
RESULTS Mitochondrial morphology screen in fly fat body tissues To systematically identify genes essential for the maintenance of mitochondrial morphology, we conducted a large-scale RNAi screen covering about 25% of the fly genes in the fly fat body tissues. We knocked down gene expression by driving UAS-dsRNA or UAS-shRNA expression in the fat body with Cg-Gal4, a fat body expressing Gal4, and marked the mitochondria with mitoGFP.
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