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Acrolein Induces Retinal Abnormalities of Alzheimer’s Disease in Mice
1. Introduction Alzheimer’s disease (AD) is the most common neurodegenerative dementia with symptoms of memory deficits, and the progressive deterioration of cognitive functions, as well as agitation and aggression. It is estimated that the number of AD patients will grow to 131 million worldwide by 2050, placing a massive burden on individuals and society [1]. According to different pathologies, AD is usually divided into familial AD (fAD) and sporadic AD (sAD) [2].
Ste20‐like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes
4 DISCUSSION This study thoroughly investigated SLK protein expression pattern and function in mouse oocytes during meiotic maturation. SLK is highly expressed in oocyte meiosis with an up-regulated phosphorylation modification and multi-site location on the nucleus, spindle and individualized chromosomes. SLK activity promotes the timely resumption of meiotic progression by inspiring the signal pathway of Plk1-CDC25C-CDK1.
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