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Layer‐by‐layer Assembly of Renal‐targeted Polymeric Nanoparticles for Robust Arginase‐2 Knockdown and Contrast‐induced Acute Kidney Injury Prevention

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By Yifan Tai, Zhen Liu, Xinyan Zhang, Xu-rui Gu
| pericles.pericles-prod.literatumonline.com
The mitochondrial enzyme arginase-2 (Arg-2) is implicated in the pathophysiology of contrast-induced acute kidney injury (CI-AKI). Therefore, Arg-2 represents a candid target for CI-AKI prevention. Here, we developed layer-by-layer (LbL) assembled renal-targeting polymeric nanoparticles to efficiently deliver small interfering RNA (siRNA), knockdown Arg-2 expression in renal tubules, and evaluated prevention of CI-AKI.
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