Xu-Zhong He on Muck Rack

Xu-Zhong He

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Perivascular spread of CSF-derived α-synuclein oligomers drives region-specific Parkinson’s-like pathology - npj Parkinson's Disease

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By Jing-Cai Meng, Rong Xue, Guo-Xing Zhang, Lin-Hui Wang, Wen-Xin Zhu, Xu-Zhong He, Yi-Xuan Dong, Jing-Ru Hou
| Nature Verified
Abstract While the level of α-synuclein oligomers (α-SOs) in the CSF of patients with Parkinson’s disease (PD) is consistently increased, its pathogenic role in PD remains poorly understood. This study focuses on the role of CSF-derived α-SOs in PD pathology. We demonstrated that CSF-derived α-synuclein enters the brain via perivascular spaces, which was more abundant in the olfactory bulb (OB) than in the substantia nigra (SN).
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