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Xuanci Bai

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Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis - npj Digital Medicine

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By Runze Huang, Qinyu Liu, Xin Jin, Yibin Wu, Yixiu Wang, Ziting Jiang, Yongfa Zhang, Yi Shi, Lu Wang, Weiping Zhu, Xuanci Bai, Xigan He
| Nature Verified
Abstract In colorectal cancer liver metastases, chromosomal instability (CIN) serves as a critical hallmark linked to tumor aggressiveness and poor prognosis. This study integrated single-cell RNA sequencing, weighted gene co-expression network analysis, and non-negative matrix factorization to construct a comprehensive CIN index, revealing that CIN-high tumor cells exhibit more aggressive phenotypes and reside in an immune-excluded tumor microenvironment.
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