Xuanyin Ding on Muck Rack

Xuanyin Ding

As seen in: Frontiers
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Articles

Branched-chain amino acid transaminases as promising targets in tumor therapy

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By Weiran Zhang, Jie Shen, Hele Liu, Xu Wang, Dan Feng, Xuanyin Ding
| Frontiers
Abstract Branched-chain amino acid transaminases (BCATs), including BCAT1 and BCAT2, play pivotal roles in tumorigenesis and therapeutic resistance in various cancers. These enzymes regulate branched-chain amino acid (BCAA) metabolism and influence critical oncogenic pathways such as mTOR, PI3K/AKT, and Wnt/β-catenin signalling. Furthermore, BCATs contribute to metabolic reprogramming, epigenetic modifications, and immune evasion.
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