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Xuecong Ren

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ATAD-3 couples plasma membrane injury to mitochondrial Ca 2+ signaling

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By Shiqi Xu, Yi Peng, Hengda Zhou, Xin Wang, Zhenguang Ying, Meijiao Li, Mao Zhang, Chonglin Yang, Weirui Ma, Suhong Xu, Xuecong Ren
| Nature Verified
Abstract Mitochondrial Ca2+ uptake couples cellular Ca2+ signals to mitochondrial metabolism and stress responses and is primarily mediated by the mitochondrial Ca2+ uniporter (MCU). Here, we identify an ATAD-3-dependent mechanism that promotes mitochondrial Ca2+ uptake following plasma membrane injury in C. elegans. Living imaging reveals robust, albeit delayed, mitochondrial Ca2+ influx following injury in mcu-1 mutants, indicating the existence of a compensatory Ca2+ uptake mechanism.
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