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Articles by Xuege Sun
In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling
Abstract Proximity labeling (PL) technologies such as APEX2 have transformed spatial multi-omics in live cells, but their long-standing dependence on hydrogen peroxide (H2O2) disrupts redox signaling and prevents use in live animals. Here we introduce H2O2-independent APEX2 (Hi-APEX), which uses a clickable tetrazine-phenol (TP) probe, requiring no enzyme engineering. We show that APEX2 directly catalyzes TP labeling without H2O2 via a mechanism requiring the probe’s tetrazine group and oxygen.
Chemical recording of pump‐specific drug efflux in living cells
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Chemical Recording of Pump‐Specific Drug Efflux in Living Cells
Conflict of Interests The authors declare no competing interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Chemical recording of pump‐specific drug efflux in living cells
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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