Ying Chen
United States
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Pulmonary injury in inflammatory bowel disease: intestinal barrier disruption, gut–lung axis remodeling, and treatment-related lung toxicity
Abstract Inflammatory bowel disease (IBD)-associated pulmonary injury is one of the frequently underestimated extraintestinal manifestations in clinical practice. It can present as subclinical pulmonary function abnormalities, radiographic changes, or overt inflammatory pulmonary diseases and often overlaps with infection- and treatment-related pulmonary toxicity, complicating early recognition and differential diagnosis.
Latent profile analysis of emergency department presentation characteristics in patients with acute ischemic stroke
Abstract Objective: This study aimed to identify potential profile types characterizing emergency department presentations among patients with acute ischemic stroke (AIS), analyze differences in demographic, clinical features, and clinical outcomes across profiles, and explore associations between presentation characteristics and prognosis (modified Rankin Scale, mRS) to inform precision intervention strategies.
RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine
1 Introduction Circadian rhythms are endogenous timing systems that allow organisms to anticipate and adapt to environmental changes following a 24-h cycle [1]. These rhythms are influenced by various environmental and metabolic stimuli, such as light and food intake, and coordinate diverse biological processes, including energy metabolism, hormone secretion, immune responses, and cell proliferation [2].
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