Xueke Yin

Abstract To determine whether intraoperative tranexamic acid (TXA) administration reduced intraoperative blood loss in patients undergoing large meningioma resection. Patients undergoing large meningioma resection face a high risk of significant blood loss. While TXA reduces blood loss and transfusion requirements in many non-neurosurgical procedures, its effect on patients undergoing supratentorial large meningioma resection remains unclear.

1 Introduction Aneurysmal subarachnoid hemorrhage (aSAH) is a potentially fatal neurological disease. Despite considerable treatment improvements over the past decades, mortality and disability rates for aSAH patients remain high [1, 2]. The reported mortality rate is 40%–45% at 30 days after bleeding and a third of the survivors have extracranial sequelae [3-5]. Besides, posttreatment cerebral infarction was strongly associated with poor outcomes.