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Xueluo Zhang

As seen in: Wiley Online Library
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Articles

Preimplantation genetic testing as a means of preventing hereditary congenital myasthenic syndrome caused by RAPSN

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By Zhiping Zhang, Xueluo Zhang, Liming Chu, Huiqin Xue
| Wiley Online Library Verified
1 INTRODUCTION Congenital myasthenic syndromes (CMS, OMIM#: 616326) constitute a group of rare inherited muscular disorders caused by genetic defects that affect the signal transmission to the neuromuscular junction (NMJ; Costain et al., 2016). The incidence rate varies with race and is approximately 0.1–1/100,000 (Pattrakornkul et al., 2020).
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Inhibition of TMUB1 blocks apoptosis and NF‐κB pathway‐mediated inflammation in recurrent spontaneous abortion

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By Xiuping Zhang, Yuanjing Hu, Zhiping Zhang, Xueluo Zhang
| Wiley Online Library Verified
Abstract Introduction Approximately 50% of cases with recurrent spontaneous abortion (RSA) have unexplained etiology. Aberrant expression of transmembrane and ubiquitin-like domain containing 1 (TMUB1) is closely related to a series of diseases, including RSA. However, the function and underlying mechanism of TMUB1 in the occurrence of RSA has not been described. Methods TMUB1 expression was detected in the placental villous tissues of 30 women with normal miscarriages and 12 women with RSA.
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