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Xuexun Chen

As seen in: Frontiers in Medicine
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Articles

Erythropoiesis-stimulating agent hyporesponsiveness in chronic kidney disease: mechanistic insights and emerging precision approaches

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By Haifeng Zhang, Zihao Zhu, Xuexun Chen, Xuan Li, Jigang Shan
| Frontiers in Medicine
Abstract Background: Erythropoiesis-stimulating agents (ESAs) remain a cornerstone of anemia management in chronic kidney disease (CKD). However, some patients show an inadequate hemoglobin response despite appropriate or increasing ESA exposure. ESA hyporesponsiveness is clinically important because persistent dose escalation may provide limited benefit while increasing treatment burden and potential cardiovascular and thrombotic risk.
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