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Foamy Monocytes and Atherogenesis in Mice With Combined Hyperlipidemia and Effects of Antisense Knockdown of apoCIII
Journal of Lipid Research 10.1016/j.jlr.2025.100763 Post-print Animals, Atherosclerosis, Hyperlipidemias, Mice, Monocytes, Humans, Apolipoprotein C-III, Receptors, LDL, Gene Knockdown Techniques, Foam Cells, Male, Oligonucleotides, Antisense, Mice, Inbred C57BL, Diet, High-Fat, Mice, Knockout, atherosclerosis, cholesterol, foam cells, inflammation, lipoproteins, monocytes, triglyceride yes Peng, Xueying; Lian, Zeqin; O'Brien, Veronica; et al., "Foamy Monocytes and Atherogenesis in Mice With...
"Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atheroscleros" by Xueying Peng, Zeqin Lian et al.
Keywords Animals, Atherosclerosis, CD36 Antigens, Hyperlipidemias, Hypertriglyceridemia, Male, Mice, Mice, Knockout, Monocytes, Poloxamer, poloxamer 407, atherogenesis, hypertriglyceridemia, foamy monocytes, lipid metabolism, monocyte phenotype Abstract Background: Hypertriglyceridemia (HTG) increases the risk for atherosclerotic cardiovascular disease, but underlying mechanisms are incompletely understood.
Inflammatory Links Between Hypertriglyceridemia and Atherogenesis
Recent studies indicate an association between hypertriglyceridemia (HTG) and atherosclerotic cardiovascular disease (ASCVD). The purpose of this review is to discuss the potential mechanism connecting HTG and ASCVD risk and the potential efficacy of HTG-targeting therapies in ASCVD prevention. HTG, with elevations in triglyceride-rich lipoproteins (TGRL) and their remnants, are causal ASCVD risk factors.
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