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Determination of Hecogenin in Mouse Blood by UPLC–MS/MS and Applied to a Pharmacokinetic Study
1 Introduction Hecogenin is a typical steroidal sapogenin mainly isolated from Agave sisalana, which has attracted increasing research attention owing to its diverse pharmacological properties (Ingawale et al. 2019; Santos Cerqueira et al. 2012). Existing pharmacological studies have confirmed that hecogenin exerts prominent anti-inflammatory (Ingawale et al. 2019), antiproliferative against multiple tumor cell lines (Bai et al. 2021), gastric mucosal protective (Santos Cerqueira et al.
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