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Xuyuan Zhang

As seen in: Nature, MDPI, ACS Publications
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Articles

Reprogramming the tumor microenvironment with antibody against membrane-proximal AXL to overcome immune checkpoint blockade resistance

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By Zuming Yang, Shuaishuai Cao, Jiaen Zhang, Xiaohua Nie, Zhimin Wang, Shaojun Yang, Jingshu Wang, Xin Sun, Huiming Huang, Zifan Wei, Pengfei Duan, Liyu Zhang, Zhenhua Ren, Xun Lan, Yang-Xin Fu, Liguo Zhang, Xuyuan Zhang, Yong Liang, Xueli Kuang, Mingwan Tang
| Nature Verified
Abstract Immune-cold tumors fail to respond to immunotherapy due to insufficient lymphocyte infiltration within the tumor tissue. Increasing the objective response rate remains an urgent challenge. Here, we report the development of a monoclonal antibody (6C5) that specifically targets the membrane-proximal epitope of the receptor tyrosine kinase AXL and modulates antitumor immunity.
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Edaphic Gradients Reshape Microbial Microenclaves Assembly within Plastispheres

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By Xuyuan Zhang, Yong Li, Ziqian Li, Yunmu Xiao
| dx.doi.org
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Edaphic Gradients Reshape Microbial Microenclaves Assembly within Plastispheres

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By Xuyuan Zhang, Yong Li, Ziqian Li, Yunmu Xiao
| ACS Publications
Abstract Click to copy section linkSection link copied! Microplastics create unique microbial habitats known as plastispheres, functioning as embedded “micro-enclaves” in soil ecosystems. However, their assembly mechanisms and ecological implications remain poorly understood. Here, we sampled microplastics and adjacent soils at 27 urban wetland sites in Changsha, China, to sequence bacterial communities and assess their assembly processes and environmental drivers.
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