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Section snippets An overview of PANoptosis as a novel therapeutic target PANoptosis is a unique innate immune inflammatory lytic cell death pathway initiated by an innate immune sensor and driven by caspases and receptor interacting protein kinases (RIPs) [1,2]. It displays collective hallmarks of three distinct forms of programmed cell death (PCD): pyroptosis (see Glossary), apoptosis, and necroptosis, hence termed PANoptosis [3,4].
Hepatitis E virus (HEV) infection causes subclinical diseases, leading to high mortality (>25%) in pregnant women. HEV replication is aggressively escalated in pregnant women, especially in the third trimester of pregnancy. Oestrogen plays an important role in pregnancy. However, the pathogenesis of HEV in pregnant women or immunosuppressive pregnant women (such as HIV‐infected or organ‐transplanted pregnant women) remains unclear.
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