To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Electroporation (EP) can alter microvascular permeability and diffusion properties of the extracellular space, possibly enhancing the enhanced permeability and retention (EPR) underlying nanoparticle uptake in tumors. Using in vitro and in vivo models, we optimized and evaluated the efficacy of EP mediated delivery of albumin bound sorafenib nanoparticles (SNP).