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Pre- and Post-synapses Contain Lecanemab-reactive Amyloid-β in Post-mortem Human Alzheimer's Disease Brain
B.D.S. has been a consultant for Eli Lilly, Biogen, Janssen Pharmaceuticals, Eisai, AbbVie and other companies and is now consultant to Muna Therapeutics. B.D.S. is a scientific founder of Augustine Therapeutics and a scientific founder and minor stockholder of Muna Therapeutics.
Association of Vessel-Specific Pericoronary Adipose Tissue Characteristics with Coronary Artery Stenosis and Plaque Composition
Abbreviation AUC (Area Under the Curve) CAD (Coronary Artery Disease) CAD-RADS (Coronary Artery Disease Reporting and Data System) CCTA (Coronary Computed Tomography Angiography) CHD (Coronary Heart Disease) CI (Confidence Interval) CP (Calcified Plaque) HU (Hounsfield Units) ICA (Invasive Coronary Angiography) IQR (Interquartile Range) LAD (Left Anterior Descending Artery) LCX (Left Circumflex Artery) NCP (Noncalcified Plaque) OR (Odds Ratio) PCAT (Pericoronary Adipose Tissue) PCATMA...
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy - Nature Neuroscience
Abstract In the neurodegenerative disease progressive supranuclear palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses are lost. We tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses.
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