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Ya'ara Negev Korem on Muck Rack

Ya'ara Negev Korem

As seen in: BioRxiv
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Articles

A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance

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By Esther Stern, Elisheva E Heilbrun, Ya'ara Negev Korem, Hadar Golan-Berman
| BioRxiv
Abstract Cisplatin [cis-diamminedichloroplatinum(II)] is a widely used chemotherapeutic agent that induces cytotoxicity primarily through DNA damage, but drug resistance severely limits its efficacy and use. Cisplatin resistance is complex and multifactorial, involving DNA repair via nucleotide excision repair (NER), and overexpression of lysine deacetylases (KDACs), which reduce chromatin accessibility and alter transcription regulation.
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