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Yachang Huo on Muck Rack

Yachang Huo

As seen in: Nature
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Articles

Tumor-intrinsic PTPN12 suppresses anti-tumor immunity in colorectal cancer by restraining a dual epigenetic and cytoskeletal dsRNA sensing program

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By Yijun Tian, Dan Wang, Yu Ping, Chaoqi Zhang, Yunbo Li, Miaomiao Li, Yaling Wang, Shumin Feng, Qitai Zhao, Kaiyuan Guo, Yujie Xu, Binhui Wang, Zhen Li, Bin Zhang, Yi Zhang, Yachang Huo, Yangfei Duan
| Nature Verified
Abstract Innate sensing of endogenous double-stranded RNA and the ensuing interferon response are crucial for the efficacy of immune checkpoint inhibition. Microsatellite stable colorectal cancer characteristically lacks this response, remaining immune-refractory with undefined intrinsic regulators.
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