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Yadu Vijayan

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Articles

Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

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By Sean Wang, Xibo Wang, Angelo Ruggieri, Ryan Brown, Cynthia Weigel, Katarzyna M. Tyc, Christiane Carter, Christopher Green, Sarah Spiegel, Yadu Vijayan
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Obesity increases circulating levels of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). Here, we identify adipocyte-expressed sphingosine kinase 2 (SPHK2), an enzyme that produces S1P, as a regulator of adipose tissue browning.
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