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Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice

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By Shigekazu Nagata, Yahiro Yamashita, Chigure Suzuki, Yasuo Uchiyama
| asm.org
Research Article | Spotlight Yahiro Yamashita, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata DOI: 10.1128/MCB.00402-19 ABSTRACT During spermatogenesis, up to 75% of germ cells in the testes undergo apoptosis and are cleared by Sertoli cells. X-linked XK blood group-related 8 (Xkr8) is a plasma membrane protein that scrambles phospholipids in response to apoptotic signals, exposing phosphatidylserine (PtdSer).
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