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Yajuan Yin

As seen in: Nature, Wiley Online Library
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Articles

Inhibition of PCSK9 protects against myocardial ischemia-reperfusion injury by suppressing ferroptosis via negative regulation of the P65/MMP9 pathway

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By Jianan Xu, Shaohui Gao, Xuan Jiang, Qian Zhang, Zelong Cao, DA LIU, Yajuan Yin, Zichang Wang, Mingqi Zheng, Tixin Gu
| Nature Verified
Abstract Ferroptosis is a critical driver of cardiomyocyte death during myocardial ischemia-reperfusion (I/R) injury. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is well-established as a key regulator of cholesterol metabolism; however, its role in modulating cardiomyocyte death, particularly ferroptosis, in the context of I/R injury remains poorly defined. Plasma PCSK9 level was determined by ELISA in patients with acute myocardial infarction 12 h after PCI.
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Tanshinone IIA inhibits foam cell formation and alleviates atherosclerosis by regulating the Hedgehog signaling pathway through TRPM2 suppression

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By Yajuan Yin, Xiao Zhang, Mei Chun Liu, Jianan Xu, DA LIU, Le Wang, Mei Wei, Gang Liu, Fangfang Ma, Mingqi Zheng, Xiaocui Shi, Wenyun Tan, Xiufang Jiang
| Nature Verified
Abstract The development of foam cells is crucial in the advancement of atherosclerosis (AS). Tanshinone IIA (Tan IIA), the primary lipophilic component of Salvia miltiorrhiza, has various pharmacological effects. Despite this, the precise role of Tan IIA in AS has not been fully elucidated. In this research, we employed ApoE−/− mice to establish an AS model. Oil Red O and HE staining indicated that Tan IIA obviously reduced plaque areas in both the aorta and aortic arch.
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Vitamin D and Atherosclerosis: Unraveling the Impact on Macrophage Function

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By Dongxia Wang, Zhen Sun, Jingyi Xiang, Yajuan Yin
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. References 1, , , , , , Signal Transduct. Target. Ther. 2022, 7, 131. 2, , , , , Circ. Res. 2016, 118, 535. 3, , , , , , , , , , , , , Eur. J. Prev. Cardiol. 2022, 29, 420. 4 G. S. Collaborators. Lancet Neurol. 2021, 20, 795. 5, , , , , , Neurology 2022, 98, e279. 6 GBD 2019 Diseases and Injuries Collaborators, Lancet 2020, 396, 1204. 7, , Pathol. Int. 2022, 72, 151. 8, , , , , , , , Int. J. Mol. Sci. 2022, 23, 3346. 9, , , , , , , , , , Eur. J. Prev. Cardiol.
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