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Articles by Yan Chang
Succinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Succinate, a key mitochondrial metabolite, is elevated in the synovial fluids of patients with rheumatoid arthritis. The mechanisms underlying biphasic proinflammatory versus anti-inflammatory signaling through the succinate receptor GPR91 have remained unresolved.
Lecanemab Reduces Neuropsychiatric Symptoms and Related Regional Brain Amyloid Load in Early Alzheimer's Disease: A Preliminary Prospective Study
1 Introduction Alzheimer's disease (AD), the primary etiology of dementia, is neuropathologically characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tau tangles [1]. Although cognitive decline is a hallmark feature, neuropsychiatric symptoms (NPS), including apathy, agitation, depression, anxiety, and psychosis, are increasingly recognized as prevalent across the AD continuum [2, 3].
[2601.00427] A Deep Learning-Enhanced Fourier Method for the Multi-Frequency Inverse Source Problem with Sparse Far-Field Data
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Lipid Nanoparticle-Mediated Targeted Delivery of MEGF10 siRNA to Astrocytes Reduced Synaptic Phagocytosis and Promoted Stroke Recovery in Mice
Biological and Medical Applications of Materials and InterfacesOctober 10, 2025 Tongtong Xu Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China Yan Chang School of Life Science and Technology & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China Runyuan Wang School of Life Science and Technology & State Key Laboratory of Advanced...
Non-Pharmacological Interventions for Fatigue in Patients with Chronic Obstructive Pulmonary Disease: a Systematic Review and Network Meta-Analysis
Keywords Chronic obstructive pulmonary disease Fatigue Non-pharmacological intervention Network Meta-Analysis Advanced care planning Palliative care Get full text access Log in, subscribe or purchase for full access. References 1. Global Strategy for Prevention Diagnosis and Management of COPD. 2024; 2. Halpin, DMG ∙ Criner, G.J. ∙ Papi, A. ... Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease.
Rapid and sensitive method for trace arsenic analysis in pharmaceutical intermediate vinyl ethyl ether by ICP-MS/MS
Abstract Vinyl ethyl ether (VEE) is a key intermediate in the synthesis of pharmaceutical compounds, making accurate determination of arsenic (As) levels in VEE essential for pharmaceutical quality control. However, highly accurate analysis of VEE is challenging owing to its high volatility and potential loss of volatile arsenic compounds.
Circular RNA DENND4C regulates cell malignant behaviors in breast canc
Back to Journals » Breast Cancer: Targets and Therapy » Volume 17 Authors Guo M, Chang Y, Dai Y, Liu X, Shi S, Li J, Liu W, Han J Received 21 May 2025 Accepted for publication 30 October 2025 Published 2 December 2025 Volume 2025:17 Pages 1145—1157 DOI https://doi.org/10.2147/BCTT.S541889 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Pranela Rameshwar MeiYan Guo,1,* Yan Chang,1,* YuNa Dai,1 Xia...
Deep learning for Parkinson’s disease classification using multimodal and multi-sequences PET/MR images - EJNMMI Research
In this retrospective study, we enrolled patients who underwent positron emission tomography / magnetic resonance (PET/MR) imaging at the People’s Liberation Army General Hospital. Imaging was performed on a GE Healthcare PET/MR scanner (SIGNA™, GE Healthcare, Milwaukee WI, United States).
Highly Sensitive Determination of Dissolved Ultra-Trace Iodine in Fuel Cell-Produced Water by High-Resolution Inductively Coupled Plasma Mass Spectrometry
Abstract Ultra-trace iodine contamination in hydrogen fuel-cell systems significantly affects the catalyst performance and membrane durability. However, current analytical methods lack sufficient sensitivity for reliable quantification and persistent memory effects compromise the accuracy. This study presents a new method that uses high-resolution inductively coupled plasma mass spectrometry to detect ultra-trace levels of iodine in fuel cell-produced water (FCW).
R²D²: Advancing Robot Mobility and Whole-Body Control with Novel Workflows and AI Foundation Models from NVIDIA Research
Welcome to the first edition of the NVIDIA Robotics Research and Development Digest (R2D2). This technical blog series will give developers and researchers deeper insight and access to the latest physical AI and robotics research breakthroughs across various NVIDIA Research labs. Developing robust robots presents significant challenges, such as: Data Scarcity: Generating diverse, real-world training data for AI models.
Precise PBAEs: A Highly Efficient Single‐Molecularly Defined Gene‐Delivery System
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature
1 Introduction Due to their remarkable success in the application of mRNA vaccines (BNT162b2 and mRNA-1273) and Patisiran, lipid nanoparticles (LNPs) have emerged as the most advanced nonviral delivery vehicles for mRNA drugs.[1-3] Classical LNPs have demonstrated high efficacy in delivering mRNA to the liver and muscles through intravenous and local injection.
Advancing Humanoid Robot Sight and Skill Development with NVIDIA Project GR00T
Humanoid robots present a multifaceted challenge at the intersection of mechatronics, control theory, and AI. The dynamics and control of humanoid robots are complex, requiring advanced tools, techniques, and algorithms to maintain balance during locomotion and manipulation tasks.
Lightweight Design for Infrared Dim and Small Target Detection in Complex Environments
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ReMEmbR shows how generative AI can help robots reason and act, says NVIDIA
Vision-language models, or VLMs, combine the powerful language understanding of foundational large language models with the vision capabilities of vision transformers (ViTs) by projecting text and images into the same embedding space. They can take unstructured multimodal data, reason over it, and return the output in a structured format.
Using Generative AI to Enable Robots to Reason and Act with ReMEmbR
Vision-language models (VLMs) combine the powerful language understanding of foundational LLMs with the vision capabilities of vision transformers (ViTs) by projecting text and images into the same embedding space. They can take unstructured multimodal data, reason over it, and return the output in a structured format. Building on a broad base of pretraining, they can be easily adapted for different vision-related tasks by providing new prompts or parameter-efficient fine-tuning.
Refined Cumulative Risk Assessment of Pb, Cd, and as in TCM Decoction Based on Bioavailability through In Vitro Digestion/MDCK Cells
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Comprehensive Hydrological Analysis of the Buha River Watershed with High-Resolution SHUD Modeling
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mechanical Properties and Damage Constitutive Model of Thermally Damaged Basalt
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A lasso and random forest model using flow cytometry data identifies primary myelofibrosis
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description cytob22173-sup-0001-FigureS1.tifTIFF image, 657.4 KB Figure S1.: Summary of the gating strategy in a PMF bone marrow. Gran: granulocytes (a) after excluding nonviable cells and debris, Various series of cell subpopulations are mapped on CD45/Side scatter (SSC) plot. (b) CD34+ cells are enumerated.
Biomedicines | Free Full-Text | Self-Cleavage of Human Chloride Channel Accessory 2 Causes a Conformational Shift That Depends on Membrane Anchorage and Is Required for Its Regulation of Store-Operated Calcium Entry
1. Introduction Human Chloride Channel Accessory 2, CLCA2, is a 943 amino acid type I transmembrane protein that plays important roles in the differentiation and stress response of mammary epithelial cells and epidermal keratinocytes [1,2,3,4]. CLCA2 is so named because it is a member of a protein family that regulates calcium-activated chloride channels [5,6].
Pharmaceuticals | Free Full-Text | GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis
Altmetric share Share announcement Help format_quote Cite thumb_up ... Endorse textsms ... Comment Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI.
Quantum-Inspired Fully Complex-Valued Neutral Network for Sentiment Analysis
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Wei Lai 1, Jinjing Shi 1,* and Yan Chang 2 1 School of Computer Science and Engineering, Central South University, Changsha 410083, China 2 Advanced Cryptography and System Security Key Laboratory of Sichuan Province, Chengdu 610025, China * Author to whom correspondence should be addressed.
Blocking Store-Operated Ca2+ Entry to Protect HL-1 Cardiomyocytes from Epirubicin-Induced Cardiotoxicity
Open AccessCommunication by Xian Liu 1,2, Yan Chang 2,3, Sangyong Choi 2, Chuanxi Cai 4, Xiaoli Zhang 5,* and Zui Pan 1,2,3,* 1 Department of Kinesiology; College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76010, USA 2 Department of Graduate Nursing, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76010, USA 3 Bone and Muscle Research Center, College of Nursing and Health Innovation, The University of...
Exogenous N-acyl-homoserine lactone-based quorum sensing regulation benefits Nitrosomonas europaea resistance to CeO2 nanoparticle acute stress
Exogenous N-acyl-homoserine lactone-based quorum sensing regulation benefits Nitrosomonas europaea resistance to CeO2 nanoparticle acute stress Huan Gao, Junkang Wu, Yan Chang, Jinyu Ye, Guangping Yang and Ran Yu Abstract Adverse effects of nanoparticles (NPs) on biological nitrogen removal (BNR) systems have been extensively explored. However, little information is available on the system’s resistance capacity and its improvement strategy to NP stresses.
A human Barrett’s esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts
Research ArticleTranslational Physiology Abstract The pathogenesis of subsquamous intestinal metaplasia (SSIM), in which glands of Barrett’s esophagus (BE) are buried under esophageal squamous epithelium, is unknown. In a rat model of reflux esophagitis, we found that columnar-lined esophagus developed via a wound-healing process involving epithelial-mesenchymal plasticity (EMP) that buried glands under ulcerated squamous epithelium.
Phytoremediation of Cadmium Contaminated Soil: Impacts on Morphological Traits, Proline Content and Stomata Parameters of Sweet Sorghum Seedlings
Abstract Phytoremediation is a green, simple, eco-friendly, sustainable, and cost-effective remediation technology to remove and degrade contaminants from soil. In this study, a germination experiment and a pot experiment were performed in greenhouse to evaluate cadmium toxicity and phytoremediation capacity. The results showed that there was the highest membership function value of cadmium (MFVC) in KFJT-3 than that of KFJT-CK and KFJT-1, the value being 0.473, 0.456 and 0.413, respectively.
In Esophageal Squamous Cells from Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion through Effects on Intracellular Calcium and a Non-Gastric Proton Pump
This paper is only available as a PDF. To read, Please Download here. ABSTRACT Background & Aims In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha (IL4Rα) have been shown to stimulate eotaxin-3 secretion via a non-gastric proton pump (ngH +,K +ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we evaluated ngH +,K +ATPase expression in EoE squamous cells, and explored molecular pathways involved in eotaxin-3 secretion by IL4Rα signaling.
Highly sensitive determination of dissolved ultra-trace phosphorus by ICP-MS with methane mixed plasma
Highly sensitive determination of dissolved ultra-trace phosphorus by ICP–MS with methane mixed plasma Phosphorus concentrations in water are usually determined using phosphomolybdenum blue (PMB) spectrophotometric. However, the measurement of extremely low phosphorus concentrations by this method is limited for various reasons, making it unable to determine low phosphorus concentrations in water samples.
Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis
Abstract Macrophages maintain a dynamic balance in physiology. Various known or unknown microenvironmental signals influence the polarization, activation and death of macrophages, which creates an imbalance that leads to disease. Rheumatoid arthritis (RA) is characterized by the massive infiltration of a variety of chronic inflammatory cells in synovia.
Fluorinated diiodine alkanes exert developmental toxicity on embryo‐larval stages of zebrafish strain AB via regulating the expression of the specific endocrine‐related genes - Lu - - Journal of Applied Toxicology - Wiley Online Library
RESEARCH ARTICLE Fluorinated diiodine alkanes exert developmental toxicity on embryo‐larval stages of zebrafish strain AB via regulating the expression of the specific endocrine‐related genes Jing Ma Corresponding Author E-mail address: jmjingma@163.com https://orcid.org/0000-0002-8006-0112 National Shanghai Center for New Drug Safety Evaluation and Research, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China Correspondence Jing Ma, National Shanghai Center...
Mechanistic insights into stress response and metabolic activity resilience of Nitrosomonas europaea cultures to CeO2 nanoparticle long-term exposure
Mechanistic insights into stress response and metabolic activity resilience of Nitrosomonas europaea cultures to CeO2 nanoparticle long-term exposure Although the negative effects of CeO2 nanoparticles (nano-CeO2) on wastewater biological nitrogen removal (BNR) system have been documented, the potential and the mechanisms of the stress tolerance and resilience of nitrifiers to nano-CeO2 exposure remain unclear.
Estrogenic effects of fluorinated diiodine alkanes in MCF‐7 cells, H295R cells and zebrafish embryo assays
The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
A seven-color panel including CD34 and TdT could be applied in >97% patients with T cell lymphoblastic leukemia for minimal residual disease detection independent of the initial phenotype
Publication HistoryPublished online: July 15, 2018Accepted: July 12, 2018; Received in revised form: June 25, 2018; Received: March 21, 2018;
Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy
Cyclic octa-peptide cyclo-[(d-Ala-L-Glu-D-Ala-L-Trp) -] and Zn2+ ions were co-assembled to form spherical nanoparticles under controlled experimental conditions. The goal was to create Zn2+-coordinated cyclic peptide nanoparticles, so that fluorescence could be generated by quantum confinement within the nanostructures. The Zn2+ ion was chosen as the metal connector due to its high affinity for complexation with carboxyl groups28.
Closed-Loop Electrochemical Recycling of Spent Copper(II) from Etchant Wastewater Using a Carbon Nanotube Modified Graphite Felt Anode
Developing effective technologies for treatment of spent etchant in printed circuit boards industries is of paramount for sustainable copper reuse and reducing copper discharge. We developed a novel closed-loop electrochemical cell for on-site regeneration of spent acidic cupric chloride etchant. It does not have any emissions and recycles all the copper using a three-dimensional graphite felt anode decorated with carbon nanotube (CNT/GF).
Assessment of the Chinese Resident Health Literacy Scale in a population-based sample in South China
The participants were residents aged 15 to 69 years who had lived in the sampled regions for more than 6 of the previous 12 months. Such individuals as patients, students, military personnel, and prisoners resident in hospitals, school dormitories, nursing homes, military bases, and prisons were excluded from the survey. We used a population-based stratified sampling frame, as shown in Fig. 1.
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