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Articles by Yan Luan
Human-AI collaborative generative AI for comfortable care: a doctor–patient–AI feedback loop for pre-operative distress and workforce shortages
Abstract Psychological screening is easily displaced by physiological safety checks when preoperative teams have little time and too few staff. Healthcare systems are already affected by widespread workforce shortages and clinician burnout. We suggest that preoperative anxiety consequently often remains unmanaged, with implications for postoperative recovery and hospital workload.
HK2 drives synaptic dysfunction in fragile X syndrome via epigenetic regulation of H3K18 lactylation
Abstract Introduction: Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of fragile X messenger ribonucleoprotein (FMRP) expression and characterized by synaptic dysfunction and cognitive impairment. However, the metabolic and epigenetic mechanisms underlying these abnormalities remain poorly understood.
The gut-heart axis: a review of the mechanisms and therapeutic prospects of gut microbiota and their metabolites in cardiovascular disease
Abstract The gut microbiota, a vital virtual organ, communicates bidirectionally with the host cardiovascular system via its intricate metabolic network, forming the gut-heart axis. This review systematically clarifies the causal relationship between gut dysbiosis and the pathogenesis of cardiovascular diseases CVD), moving beyond epidemiological associations to solid causal evidence from preclinical and clinical studies.
Unlocking Governance for Sustainability in the Digital Age: How e-Government Shapes Inclusive Human Development in Africa
1 Introduction Despite more than two decades of positive economic growth experienced by many developing countries, evidence shows that expected inclusive development benefits of this growth have not materialized as inequality and extreme poverty continue to rise in several parts of the developing world, especially in Africa (OXFAM 2021; O'Donovan 2025).
Inverse and dynamic levels of H3K4me3 and H3K27me3 regulate mouse postnatal dental gyrus development - Cell Death & Differentiation
Abstract The dentate gyrus (DG), a crucial region of the hippocampus responsible for learning, spatial encoding, and memory formation, undergoes its main development and maturation after birth. Despite its importance, the regulatory mechanisms underlying postnatal DG development remain poorly understood. This study is aimed to investigate the role of H3 lysine 4 trimethylation (H3K4me3) and H3 lysine 27 trimethylation (H3K27me3) in the development and function of the postnatal DG.
UTX inhibition suppresses proliferation and promotes apoptosis in patient‐derived glioblastoma stem cells by modulating periostin expression
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jcp31178-sup-0001-Figure_S1.tif23.9 MB Supporting information. jcp31178-sup-0002-Figure_S2.tif15.9 MB Supporting information. jcp31178-sup-0003-Figure_S3.tif33 MB Supporting information. jcp31178-sup-0004-Figure_S4.tif22.7 MB Supporting information. jcp31178-sup-0005-R-fig_S5.jpg1.2 MB Supporting information.
CCN3/NOV Regulates Proliferation and Neuronal Differentiation in Mouse Hippocampal Neural Stem Cells via the Activation of the Notch/PTEN/AKT Pathway
Abstract : Neural stem cells (NSCs) persist in the subgranular zone (SGZ) throughout the lifespan and hold immense potential for the repair and regeneration of the central nervous system, including hippocampal-related diseases. Several studies have demonstrated that cellular communication network protein 3 (CCN3) regulates multiple types of stem cells. However, the role of CCN3 in NSCs remains unknown.
Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression
ORIGINAL ARTICLE Xinlin Chen Corresponding Author E-mail address: chenxl@mail.xjtu.edu.cn https://orcid.org/0000-0001-7990-101X Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China Correspondence to Dr. Xinlin Chen, Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Xi'an, Shaanxi 710061, China Email: chenxl@mail.xjtu.edu.cn Search for more papers by this author This article has been accepted for...
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis
Highlights • CmAb-(IL10) 2 prolongs the half-life of IL-10 and minimizes its toxicity • Tumor-targeted IL-10 induces superior antitumor effects over nontargeted IL-10 • CmAb-(IL10) 2 prevents tumor-specific CD8 + TILs apoptosis through IL-10R on DCs • CmAb-(IL10) 2 overcomes resistance to immune checkpoint blockade Summary Increasing evidence demonstrates that interleukin-10 (IL-10), known as an immunosuppressive cytokine, induces antitumor effects depending on CD8 + T cells.
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