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Articles by Yang Eric
Heterogeneous Slowdown of Dynamics in the Condensate of an Intrinsically Disordered Protein
The discovery of membraneless organelles (MLOs) has changed cellular biophysics, (1) challenging the traditional view that cellular compartmentalization is exclusively mediated by lipid-bound organelles and vesicles. MLOs are high-density liquid droplets formed through the process of liquid–liquid phase separation (LLPS) (2−6) of proteins, particularly intrinsically disordered proteins (IDPs), (7,8) and RNA. (9) They play critical roles in orchestrating various cellular processes.
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity | Proceedings of the National Academy of Sciences
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity Ramya Raviram, Anugraha Raman, Sebastian Preissl, +23 , Jiangfang Ning https://orcid.org/0000-0001-5199-7742, Shaoping Wu, Tomoyuki Koga https://orcid.org/0000-0002-8330-117X, Kai Zhang https://orcid.org/0000-0003-3454-7357, Cameron W.
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity | Proceedings of the National Academy of Sciences
Skip to main content Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity Ramya Raviram, Anugraha Raman, Sebastian Preissl, +23 , Jiangfang Ning https://orcid.org/0000-0001-5199-7742, Shaoping Wu, Tomoyuki Koga https://orcid.org/0000-0002-8330-117X, Kai Zhang https://orcid.org/0000-0003-3454-7357, Cameron W.
DNA methylation atlas of the mouse brain at single-cell resolution - Nature
Abstract Mammalian brain cells show remarkable diversity in gene expression, anatomy and function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly understood.
An atlas of gene regulatory elements in adult mouse cerebrum - Nature
Abstract The mammalian cerebrum performs high-level sensory perception, motor control and cognitive functions through highly specialized cortical and subcortical structures1.
Comparative cellular analysis of motor cortex in human, marmoset and mouse - Nature
Abstract The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome.
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