Yang Zhao on Muck Rack

Yang Zhao

  • Editor, Tencent
As seen in: Arthritis & Rheumatology, Color Research & Application, Nature, Wiley, Wiley Online Library, PLOS Biology, PLOS ONE, CGTN, European Journal of Vascular and Endovascular Surgery
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Articles

Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer

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By Yixin Zhang, Pan Gu, Yang Zhao, David C. Christiani, Feng Chen, Sipeng Shen, Jinglan Dai
| Nature Verified
Abstract Polygenic risk scores (PRSs) quantify genetic susceptibilities, yet ancestry imbalance in genome-wide association studies (GWASs) limits the accuracy of monoracial PRSs in non-European populations. Here, we perform a multiancestry GWAS meta-analysis for lung cancer (76,953 cases and 1,886,372 controls), identifying 87 conditionally independent genome-wide significant loci, including two unreported cytobands.
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Magnetic resonance imaging radiomic phenotypes stratify response and define immune states in very high‐risk, nonmuscle-invasive bladder cancer treated with tislelizumab plus nanoparticle albumin‐bound paclitaxel - Huang - 2026 - Cancer - Wiley Online Libr

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By Shiwang Huang, Shan Liang, Zhe Zhang, Ning Kang, Zhouliang Wu, Yuda Lin, Peng Li, Zihan Xue, Houyuan Chen, Yang Zhao, Jianing Guo, Changping Li, Jingmin Cui, Guoping Xu, Yunkai Qie, Kaipeng Jia, Boyue Ma, Huitong Chen, Wang Chai
| Wiley Online Library Verified
Magnetic resonance imaging radiomic phenotypes stratify response and define immune states in very high‐risk, nonmuscle–invasive bladder cancer treated with tislelizumab plus nanoparticle albumin‐bound paclitaxel - Huang - 2026 - Cancer - Wiley Online Library
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YBX1 Confers immunosuppressive bone metastatic traits in non-small cell lung cancer

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By Kai Zhang, Qingshui Wang, Xiuli Zhang, Mengyao Lv, Mengyang Huang, Zihui Liang, Zijie Xie, Yao Lin, Yang Zhao, LiLin Ge, JING CHEN
| Nature Verified
Abstract The spread of lung cancer to bone is a devastating complication often linked to resistance against immunotherapy, but the reasons for this connection are poorly understood. Here we show that the transcription factor YBX1 acts as a central regulator driving both bone metastasis and the formation of an immunosuppressive environment in non-small cell lung cancer (NSCLC). YBX1 achieves this by activating distinct signaling pathways (IL6 and CCL5, respectively).
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