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Yangdon Tenzin on Muck Rack

Yangdon Tenzin

As seen in: BioRxiv
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Articles

Rational protein engineering to enhance MHC-independent T cell receptors

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By Jack H Landmann, Jufang Chang, Tien-Ching Chang, Yangdon Tenzin
| BioRxiv
Abstract Chimeric antigen receptor (CAR)-based therapies have pioneered synthetic cellular immunity against cancer, however remain limited in their scope and long-term efficacy. Emerging data suggest that dysregulated CAR-driven T cell activation causes T cell dysfunction and therapeutic failure. To re-engage the endogenous T cell response, we designed hybrid MHC-independent T cell receptors (miTCRs) by linking antibody variable domains to TCR constant domains.
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