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Yanglan Tan

As seen in: BioRxiv
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Articles

Rit2 loss in dopaminergic neurons drives a Parkinsonian phenotype

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By Patrick J. Kearney, Yuanxi Zhang, Yanglan Tan, Elizabeth Kahuno
| BioRxiv
Abstract Parkinson′s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc). Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression loss to a PD patient cohort. However, it is still unknown whether Rit2 loss itself is causative for PD or PD-like symptoms.
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Rit2 loss in dopaminergic neurons drives a progressive Parkinsonian phenotype

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By Patrick J. Kearney, Yuanxi Zhang, Elizabeth Kahuno, Yanglan Tan
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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