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Sulfamethoxazole (SMX), a widely utilized bacteriostatic antibiotic, has played a pivotal role in effectively treating diseases caused by bacteria [1]. Over the past few decades, global production and usage of sulfonamide antibiotics, such as SMX, have witnessed a considerable rise for both human and veterinary applications [2]. However, duo to its limited bioavailability in humans and animals, only about 10–50 % of the administered dose was metabolized [3].
With the pressing issue of addressing climate change and limiting global temperature increase to 1.5 °C by 2050, achieving net-zero emissions has become an urgent priority [1]. Considering renewable energy faces technical challenges and may not have a significant impact on energy supply, fossil fuels are expected to continue dominating the global chemical industry in the near future [2], [3].
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