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Yangshuai Gao

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Articles

Immune-stimulatory cytokine IL-18 induces inflammatory senescence and impairs stem cell-mediated experimental skeletal regeneration

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By Liang Wang, Yaokai Gan, Qixuan Lin, Shaokang Chen, Mingheng Li, Jiahan Chen, Hang Shen, Quan Zheng, Dimitri Sokolowskei, Robert J. Tower, Minjun Huang, Jiankun Xu, Aaron James, Xiaochun Bai, Zhongmin Zhang, Jiajia Xu, Yangshuai Gao
| Nature Verified
Abstract Stem cell–based therapies offer potential for repairing large skeletal defects, yet persistent inflammation limits their efficacy. Here, we identify macrophage–derived IL-18 as an immune switch that impairs skeletal regeneration by disrupting immune–mesenchymal cell interactions. IL-18 is elevated in male mouse non-healing models and human bone nonunion samples, supporting its translational relevance.
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