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Articles by Yangwu Chen
A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models
Editor’s summary Repairing the enthesis, the fibrocartilage junction between tendon and bone, remains a major clinical challenge. Here, Zhang et al. evaluated nanoscale enthesis structure and chemical composition to develop a bioinspired mineralized collagen scaffold for fibrocartilage regeneration. In small- and large-animal preclinical models, the mineralized scaffold achieved more fibrocartilage regeneration than other biomaterial approaches, leading to better joint mechanics and function.
Biomimetic Intrafibrillar Mineralization of Native Tendon for Soft-Hard Interface Integration by Infiltration of Amorphous Calcium Phosphate Precursors - Chen - Advanced Science - Wiley Online Library
1 Introduction Regenerating the tendon-bone junction remains a persistent challenge due to its complex hierarchical gradient structure, which comprises the tendon, non-calcified fibrocartilage, calcified fibrocartilage, and bone tissue.[1] The gradient transition of these four components provides for the smooth transmission of forces produced by the muscle to the bone through the tendon, thereby preventing tissue rupture caused by stress concentration.[2] However, the intricacy of this...
An In Situ Electrochemical Amorphization Electrode Enables High‐Power High‐Cryogenic Capacity Aqueous Zinc‐Ion Batteries
Abstract Quick-charge technology is of great significance for the development of aqueous zinc-ion batteries. In this study, an unreported in situ electrochemical amorphization mechanism is highlighted to unlock the ultrafast-kinetics electrode. Multiple characterizations, density functional theory calculation, and molecular dynamic simulation are applied to uncover the storage mechanism of electrodes, as well as the evolution of structure, and reaction kinetics after reconstruction.
A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation
We also re-clustered the mature tendon clusters fibroblast 2 and fibroblast 3, which are mainly composed of P14 tendon cells. Three groups with different levels of the classic tendon molecular collagen were identified (Figure S4A). Cells in subcluster 1 showed the highest expression of Col1a1 and, thus, were annotated as the Col1a1+ cluster (Figure S4C). Tnmd and Lox were also highly expressed in this cluster, corresponding to the collagen fibril and ECM organization functions.
Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification
Abstract Heterotopic ossification (HO) in connective tissues like tendons and ligaments severely damages tissue structure. The pathogenesis of HO remains unclear but may involve mTOR. The results presented here indicate that tendon stem/progenitor cells do not undergo osteochondrogenic differentiation when mTOR signaling is inactivated by gene knockout or rapamycin (RAPA) treatment. Meanwhile, it is necessary to deliver RAPA to the injured sites and avoid disturbing the normal tendon.
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