Yangyumeng Chen

Abstract Gut microbes encode a variety of systems for molecular sensing and controlling conditional gene expression within the mammalian gut. Synthetic biology approaches such as whole-cell biosensing and 'sense-and-respond' therapeutics aim to tap into this vast sensing repertoire to drive clinical and pre-clinical applications. An ongoing constraint is the limited number of well-characterized inducible circuit components to specifically sense in vivo conditions of interest, such as disease.

Abstract Gut-resident microbes encode a variety of systems capable of sophisticated sensing and conditional gene expression control within the mammalian gut during health and disease. Bacterial synthetic biology approaches, such as whole-cell biosensing and 'sense-and-respond' therapeutics, aim to re-purpose such systems for research and clinical applications; however, the toolbox of well characterised in vivo and disease-related inducible systems remains limited.