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Yanning Yin

As seen in: Nature, Physical Review B
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Articles

Cell-free DNA fragmentomics for preeclampsia risk assessment

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By Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu, Wuyan Huang, Quanfu Zhang
| Nature Verified
Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited. Here we show that generating relatively stable cell-free DNA (cfDNA) fragmentomic metrics, including transcription start site (TSS) coverage, TSS score, and Gini coefficient, required 600 million whole-genome sequencing reads of plasma cfDNA.
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Experimental implementation of laser cooling of trapped ions in strongly inhomogeneous magnetic fields

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By Richard Karl, Stefan Willitsch, Christian Mangeng, Yanning Yin
| Physical Review B
We demonstrate the Doppler laser cooling of Ca+40 ions confined in a segmented linear Paul trap in the presence of a strong quadrupolar magnetic field generated by two permanent ring magnets. Magnetic field gradients of 800 to 1600 G/mm give rise to a highly position-dependent Zeeman shift on the energy levels of the trapped ions. Efficient laser cooling is demonstrated using two 397 nm cooling laser beams with appropriate wavelengths and polarizations and one 866 nm repumper laser beam.
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