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Articles by Yanping Sun
Obsessive-compulsive symptoms and sleep disturbance in college freshmen: a cross-sectional conditional process analysis
Abstract Sleep disturbance is common among college students, but the statistical relationships linking obsessive-compulsive symptoms (OCS), affective symptoms, and problematic Internet use remain unclear in nonclinical freshmen. In this cross-sectional study, 9,418 college freshmen aged 18–23 years (M = 19.60, SD = 0.65; 3,660 females) completed relevant subscales of the Chinese College Students’ Mental Health Screening Scale.
An iron-regulated methionine redox axis governs adipose browning and cancer cachexia
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Abstract Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological and cachectic settings.
By Jung Seung Nam, Sung Shin Ahn, Yeonoh Shin, Ariana Vargas-Castillo, Maya Dixon, Kathrin Schilling, Fereshteh Zandkarimi, Alex B. Chen, Nal Ae Yoon, Harrison B. Cullen, Yanping Sun, Thomas Caffrey, Kelsey A. Klute, Benjamin Swanson, Samuel S. Pan, Yuxuan Chen, Geena Kim, Kazuki N. Sugahara, Michael Kluger, Paul M. Grandgenett, Michael A Hollingsworth, Luke E. Berchowitz, Lori M. Zeltser, Sabrina Diano, Pardis Ahmadi, Jordan Lu, Shu Ichimiya, Anthony W. Ferrante Jr.
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Nature
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Limited discriminant validity of health belief and 3C models in high HPV vaccine coverage settings: the moderating role of hukou and structural barriers
Abstract Background: Whether traditional health belief models (HBM) and 3C models can distinguish residual non-vaccinators in settings with >70% HPV vaccine coverage is unknown. The moderating role of China’s household registration (hukou) on psychological factors and behavior has rarely been quantified. Methods: From April 2025 to February 2026, we surveyed 1,257 women aged 18–65 from six Shenzhen communities.
Research progress of antibacterial hydrogels in diabetic wound infection
Abstract Chronic wound infections in diabetes present significant clinical challenges due to their complex pathological microenvironment. Intelligent hydrogel dressings, with their three-dimensional network structure and high designability of functions, provide an innovative solution for diabetic wound management. This review systematically elaborates on the latest research progress of antibacterial hydrogels.
Chemistry-informed deep learning model for predicting stereoselectivity and absolute configuration in asymmetric hydrogenation
3 hours ago Just like we did with the early internet, we’re again missing out on the promise and power of local, decentralized technology. We’ve been here before. At so many pivotal moments in our adoption of digital technology, people and businesses mistake a company’s walled garden for the broader, more …
Albumin-based nanoparticles: a potential and emerging oral drug delivery system
Abstract Objective The purpose of this review is to elaborate current development and challenges of oral albumin nanoparticles, and realize their clinical application. Significance Albumin is an emerging protein nanocarrier with a high degree of versatility, safety, stability, modifiability. These characteristics endow albumin nanoparticles with considerable attention and unique roles in drug delivery.
Fully-Packed Ultrasmall Au Nanoclusters in Covalent Organic Frameworks as Positive Electrodes for Supercapacitors
Fully-Packed Ultrasmall Au Nanoclusters in Covalent Organic Frameworks as Positive Electrodes for Supercapacitors Supported metal nanoclusters have emerged as highly promising class of materials with great potential across a wide range of applications including electrochemistry. However, fully-metal-loading of supports with ultrasmall pore structures, such as covalent organic frameworks (COFs), which might yield new performances, remains a challenge.
Leveraging T cell co-stimulation for enhanced therapeutic efficacy of trispecific antibodies targeting prostate cancer
Methods The prostate cancer cell lines LNCaP, 22Rv1, and C4-2B were gifted by Prof. Dan Li at Zhejiang University. Cells were cultured in RPMI-1640 (Gibco) supplemented with 10% FBS (Gibco) and 1% penicillin/streptomycin solution (Solarbio). Human PBMCs from healthy donors were purchased from Sailybio. Cells were maintained in a humidified chamber at 37°C with 5% CO2. The reagent sources and catalog numbers are listed in online supplemental table S2.
Human Induced Pluripotent Stem Cells: Directed Differentiation Methods and Applications in Brain Diseases
Conflicts of Interest Xiaokun Cheng is an employee of North China Pharmaceutical Group Corporation. Supporting Information Filename Description jnr70027-sup-0001-Supinfo.docxWord 2007 document , 1.7 MB Data S1. References , , , , and . 2009. “Motor Neurons With Axial Muscle Projections Specified by Wnt4/5 Signaling.” Neuron 61, no. 5: 708–720. https://doi.org/10.1016/j.neuron.2008.12.026. , , , et al. 2013.
Recent Advances in Alkaloids from Papaveraceae in China: Structural Characteristics and Pharmacological Effects
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Isovaleryl Sucrose Esters from Atractylodes japonica and Their Cytotoxic Activity
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Nanotube Topography Rejuvenates the Senescence of Mesenchymal Stem Cells by Activating YAP Signalling
Nanotube Topography Rejuvenates the Senescence of Mesenchymal Stem Cells by Activating YAP Signalling Improving the regenerative ability of senescent stem cells is a critical issue in combating aging. The destiny and function of senescent stem cells are controlled by the niche, including the physical architecture of the surface of the extracellular matrix (ECM).
Antioxidants | Free Full-Text | Artesunate Exerts Organ- and Tissue-Protective Effects by Regulating Oxidative Stress, Inflammation, Autophagy, Apoptosis, and Fibrosis: A Review of Evidence and Mechanisms
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Acvr1b loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin
Abstract Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) can develop from precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). Previous studies indicated that loss of Acvr1b accelerates the Kras-mediated development of papillary IPMN in the mouse pancreas, however, the cell type predominantly affected by these genetic changes remains unclear.
Iridium-Catalyzed Reductive β-alkylation of (Iso)quinoline Derivatives by an in situ Enone-trapping Strategy
Iridium-Catalyzed Reductive β-alkylation of (Iso)quinoline Derivatives by an in situ Enone-trapping Strategy By employing [IrCp*Cl2]2/Mg(OMe)2/(CH2O)n as an applicable catalyst system, we report a reductive β-alkylation of (iso)quinolinium salts with the cost-effective and readily available β-chloro ketones, proceeding with good chemo-selectivity, mild reaction conditions, and no need for introduction of a substituent at position-3 of the quinolyl skeleton.
Bimetallic Coordination Polymers: Synthesis and Applications in Biosensing and Biomedicine
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Acvr1b loss promotes formation of precancerous lesions from acinar and ductal cells of origin
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Response of mesenchymal stem cells to surface topography of scaffolds and the underlying mechanisms
Response of mesenchymal stem cells to surface topography of scaffolds and the underlying mechanisms Li Xiao,a Yanping Sun,a Li Liao a and Xiaoxia Su *a Abstract Mesenchymal stem/stromal cells (MSCs) serve as essential components of regenerative medicine. Their destiny is influenced by the interaction of the cells with the external environment.
Portable point-of-care diagnostic devices: an updated review
Portable point-of-care diagnostic devices: an updated review Tong Shu,ab Haley Hunter,c Ziping Zhou,ab Yanping Sun,ab Xiaojun Cheng,ab Jianxin Ma,ab Lei Su,a Xueji Zhang a and Michael J. Serpe *c Author affiliations * Corresponding authors a Research Center for Biosensor and Nanotheranostic, Shenzhen Key Laboratory for Nano-Biosensing Technology, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P. R.
Bioreducible Poly(amido amine) Copolymers Derived from Histamine and Agmatine for Highly Efficient Gene Delivery
The histamine (HIS) can facilitate the endosomal escape of polyplexes via “proton sponge effect” because of its imidazole groups. Agmatine (AGM) can improve the transmembrane process of polyplexes due to its guanidinium groups. Therefore, HIS and AGM were used as amino monomers to react with cystamine bisacrylamide (CBA) through Michael addition.
Weak Grip Strength and Cognition Predict Functional Limitation in Older Europeans
In Europe, the proportion of older adults has increased from approximately 16.0% in 1980 to more than 24.7% in 2017, to the point where approximately 1 in every 4 Europeans is aged 60 and older.1 As people age, they are more likely to have functional limitation such as difficulty with walking, climbing, and balance and with fine motor skills.2 As a substantial impairment in an individual's ability to perform major life activities effectively,3 is has been believed that functional limitations...
In vivo detection and automatic analysis of GABA in the mouse brain with MEGA-PRESS at 9.4 T
The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher–Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of ?-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthesia.
Thiol Michael Addition Reaction: A facile Tool for Introducing Peptides into Polymer-based Gene Delivery Systems
Polymers, as widely used non-viral gene carriers, are suffered from high cytotoxicity and relatively low transfection efficiency. Such crucial drawbacks of polymers could be solved by incorporating short and bioactive peptides. The resulted synthetic polymer-peptide conjugates can not only maintain their own special characteristics, but also gain novel characteristics far beyond their parent polymer and peptide components to overcome barriers of gene delivery.
Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells
A novel alkali extractable polysaccharide (designated as PNA-2) was purified from Pleurotus nebrodensis and the effects of purified PNA-2 on the proliferation and apoptosis of human hepatic cancer cells (HepG2) were investigated in this study. The results of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that PNA-2 inhibited the proliferation of HepG2 cells by apoptosis induction, which was also characterized using scanning electron microscopy (SEM).
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