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Yanying Huang on Muck Rack

Yanying Huang

As seen in: Nature
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A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial - Nature Communications

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By Feng Chen, Yao Liu, Ziwei Zhou, Jia Liao, Xinran Fan, Yanying Huang, Yifei Chen, Jingyu Chen, Jian-Rong Yang
| Nature Verified
Abstract Each amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches the cellular tRNA supply. Here we hypothesize instead that the optimal CUB of a gene should slightly mismatch the tRNA supply to avoid excessive translational costs, while ensuring adequate functional payoff.
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