Yaoyu Yin

Abstract Foscarnet is a clinically vital antiviral drug with substantial market value, yet its conventional synthesis remains challenging. The coupling of CO2 with phosphite represents an attractive and sustainable alternative route for foscarnet production, although this approach has not been successfully demonstrated so far. Here we show the electrosynthesis of foscarnet via the coupling of CO2 and phosphite, enabled by an ionic liquid-modified bismuth (IL@Bi) catalyst.

Abstract The electrochemical co-reduction of CO2 and N2 to urea presents a sustainable alternative to conventional synthesis but faces substantial challenges. Here we design a catalyst by anchoring the ionic liquid (IL) 1-ethyl-2,3-dimethylimidazolium bromide onto a CuBi surface. The IL@CuBi catalyst delivers an exceptional Faradaic efficiency toward urea (FEurea) of 73.0% and a current density of 27.4 mA cm−2 in an H-type cell, with a production rate of 124.7 μmol cm−2 h−1.

Conflict of Interests The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description anie70618-sup-0001-SuppMat.docx3.5 MB Supporting Information References 1, , , Angew. Chem. Int. Ed. 2022, 61, e202112835, https://doi.org/10.1002/anie.202112835.