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Yaping Zhi on Muck Rack

Yaping Zhi

As seen in: Nature
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Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells

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By Wang Wang, Baida Kong, Changyuan Huang, Chuanxin Su, Yang Lu, Huimin Wang, Qi Long, Haoran Sun, Qi Hu, Julie Wang, Wenxi He, Chi Zhou, Yiding Xiong, Li Zhou Verified, Xin McRae Chen, Peng Wang, Bing-Hua Jiang, Lianhui Sun, Shimon Sakaguchi, Song Zheng, Ke-Xu Xiong, Rongzhen Liang, Chuanye Zhang, Linyu Sha, Yaping Zhi
| Nature Verified
Abstract Tumor metastasis is the leading cause of death for more than 90% of cancer patients, with colorectal cancer (CRC) mainly spreading to the liver. The colon and liver possess distinct nutritional microenvironments, yet how these differences shape the tumor immune landscape remains unclear. Using single-cell analysis of autologous samples from CRC patients with liver metastases, we identified a distinct CD177+GK+ regulatory T (Treg) cell subset in metastatic lesions.
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