Yardenna Dolev on Muck Rack

Yardenna Dolev

As seen in: Wiley Online Library
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Articles

Reply to “Metformin as a booster or obstacle of immunotherapy in patients with non-small cell lung cancer and diabetes mellitus”

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By Yasmin Leshem, Yardenna Dolev, Nava Siegelmann-Danieli, Sarah Moser
| Wiley Online Library
REPLY Reply to “Metformin as a booster or obstacle of immunotherapy in patients with non–small cell lung cancer and diabetes mellitus” Yasmin Leshem MD, PhD, Yasmin Leshem MD, PhD Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Department of Immunology, Weizmann Institute of Science, Rehovot, Israel Search for more papers by this authorYardenna Dolev MD, Yardenna Dolev MD Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Search for more papers by this...
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Association between diabetes mellitus and reduced efficacy of pembrolizumab in non-small cell lung cancer

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By Yasmin Leshem, Yardenna Dolev, Nava Siegelmann-Danieli, Sarah Moser
| Wiley Online Library
DISCUSSION We report here that DM is associated with reduced efficacy in metastatic NSCLC patients treated with first-line pembrolizumab in both a single-center retrospective study and a validation cohort from a nationally distributed health care service. Unlike other modes of treatments, including chemotherapy and targeted therapy, immunotherapy modifies the host and only indirectly influences cancer cells.
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