Yaser Mansuroglu

1. Introduction Hot-melt extrusion is a well-established tool in the pharmaceutical industry, mostly implemented to increase the solubility of poorly soluble drugs [1,2,3]. In this process, a mixture of the active pharmaceutical ingredient (API), a polymer (often based on acrylates, lactic acid, or cellulose derivatives) and a plasticizer, e.g., stearic or triethyl citric acid, is continuously fed into a single or twin-screw extruder and melted at a specific temperature.