Yasser El Hadeg on Muck Rack

Yasser El Hadeg

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Articles

Substrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa - Nature Communications

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By Rafal Zdanowicz, Pavel Afanasyev, Daniel Boehringer, Alexander Leitner, Rudi Glockshuber, Yasser El Hadeg
| Nature Verified
Abstract Mycobacteria harbor a proteasome that was acquired by Actinobacteria through horizontal gene transfer and that supports the persistence of the human pathogen Mycobacterium tuberculosis within host macrophages. The core particle of the proteasome (20S CP) associates with ring-shaped activator complexes to degrade protein substrates. One of these is the bacterial proteasome activator Bpa that stimulates the ATP-independent proteasomal degradation of the heat shock repressor HspR.
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