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Yat Long Tsoi

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Articles

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors - Nature Cell Biology

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By Christine M. Poch, Karin Jennbacken, Qing-Dong Wang, Anna Bettina Meier, Yat Long Tsoi, Daniel Hovdal, Elif Inan Eroglu, Eckhard Wolf, Andreas Dendorfer, Marco Gaspari, Giovanni Cuda, Daniel Sinnecker, Christian Kupatt, Regina Fritsche-Danielson, Alessandra Moretti, Karl-Ludwig Laugwitz
| Nature Verified
Abstract Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains elusive. Here, by combining lineage tracing and single-cell transcriptomics in injured non-human primate heart biomimics, we uncover the coordinated action modes of human progenitor-mediated muscle repair.
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