Yatharth Mahajan

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GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents

Oct 24, 2025 |

By Shaurya Mahajan, Alireza Sharafshah, Keerthy Sunder, Yatharth Mahajan

| preprints.org

Background: GLP‑1 receptor agonists (GLP‑1RAs) are effective for type 2 diabetes and obesity and engage central stress and reward pathways (HPA axis; mesolimbic dopamine). Psychiatric signals have been reported in some settings.

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Yatharth Mahajan

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GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents

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