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Yawen Chen

Verified
London
As seen in: Breakingviews, Reuters, MSN, MSN Canada, MSN UK, Business Insider, Cinco Días, Daily Mail, ETRealty, MSN España, MSN South Africa, Nature and
Columnist @Reuters @Breakingviews. Views subject to change on new evidence/data. 世事洞明皆学问
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Articles

ASB2 inhibits lipid accumulation to promote ILC1 homeostatic fitness and anti-tumor immunity in the mouse liver

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By Boqun Bao, Xianwei Wang, Yawen Chen Verified, Xiaodong Zheng, Yongyan Chen, Haoyu Sun, Guoliang Cui, Rui Sun, Zhigang Tian, Hui Peng
| Nature Verified
Abstract Type 1 innate lymphoid cells (ILC1) are abundant in the adult liver and are pivotal for immune surveillance and modulation, but the regulation of their maintenance and functionality remains underexplored. Here, we re-analyze published single-cell RNA- sequencing data and find increased expression of Asb2 in ILC1s from adult mouse livers. Conditional ablation of Asb2 in NKp46+ cells, depleting ASB2 in ILC1s and NK cells, in mice impairs ILC1 survival and reduces adult liver ILC1 numbers.
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Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii

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By Jie Pang, Yawen Chen Verified, Dengcheng Zhou, Lijue Wang, Yuling Xiao, Zhibo Zhang, Zhaxi Zerang, Lele Zhang, Xiang Gu, Min Xiao, Jingyu Wang, Hui Cui, Aijia Wen, Shouyue Zhang, Yiwen Zhang, Binwu Ying, Liang Ouyang, Xiawei Wei, Bi-Sen Ding, Xiaodi Tang, Haohao Dong, Maolin Duan
| Nature Verified
Abstract Acinetobacter baumannii is a critical-priority pathogen with increasing antibiotic resistance. Here, we define the mechanism of abaucin, a first-in-class narrow-spectrum antibiotic that selectively targets A. baumannii by inhibiting its essential lipoprotein transporter, LolDF. Extending prior studies of archived strains, we demonstrate potent activity against clinically isolated carbapenem-resistant A. baumannii (CRAB) strains both in vitro and in a murine pneumonia model.
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Μια νέα συμφωνία μεταξύ ΗΠΑ και Ιράν θα μπορούσε να αποδειχθεί εξίσου άχρηστη με την προηγούμενη

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By Yawen Chen Verified
| ot.gr
Reuters Breakingviews Φαίνεται ότι οι ΗΠΑ και το Ιράν βρίσκονται κοντά στην επίτευξη συμφωνίας. Το Reuters μετέδωσε την Πέμπτη, επικαλούμενο τέσσερις πηγές που είναι ενήμερες για το θέμα, ότι οι δύο πλευρές ενδέχεται να παρατείνουν την εκεχειρία κατά 60 ημέρες και να άρουν τους περιορισμούς στα Στενά του Ορμούζ. Οι έμποροι πετρελαίου και οι επενδυτές σε μετοχές μπορεί να πανηγυρίζουν, αλλά κινδυνεύουν να βιαστούν υπερβολικά. Αφενός, το μνημόνιο κατανόησης ενδέχεται να μην υπογραφεί ποτέ.
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