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Yaxiong Gao on Muck Rack

Yaxiong Gao

As seen in: Frontiers
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Articles

Precision-targeted nanodelivery systems for intra-articular treatment of knee osteoarthritis: recent breakthroughs and translational challenges

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By Yongli Zhao, Yaxiong Gao, Wenhua Zhao, Fadong Li, Tiansheng Bu, WeiBing Hou
| Frontiers
Abstract Knee osteoarthritis (KOA) is a progressive whole-joint disorder characterized by cartilage degeneration, synovial inflammation, subchondral bone remodeling, and pathological alterations of the intra-articular (IA) microenvironment. Conventional IA therapies—including corticosteroids, hyaluronic acid, and emerging biologics—provide only transient relief due to rapid synovial clearance, poor cartilage penetration, and limited targeting specificity.
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Microneedle-based transdermal delivery systems for metabolic bone diseases: advances, challenges, and future perspectives

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By Qiang Zhou, Qiang Liu, Min Liu, Hui Wang, Naijia Liu, Yanping Zhu, Yongli Zhao, Xingwen Xie, Xianli Zheng, Dingpeng Li, Yaxiong Gao
| Frontiers
Abstract Metabolic bone diseases (MBDs), such as osteoporosis and rickets, present significant clinical challenges due to the chronic nature of treatment and the limitations of conventional systemic therapies. Oral medications often suffer from low bioavailability and gastrointestinal intolerance, while injectable biologics are hampered by poor patient adherence. Microneedle (MN) systems have emerged as a transformative transdermal delivery platform capable of overcoming these barriers.
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