Yaying Hong

Abstract Prostate cancer (PCa) is a common malignancy in men, and bone metastasis is a leading cause of mortality in advanced-stage PCa. This study aims to identify critical genes involved in PCa bone metastasis, exploring biomarkers for prognosis and precision treatment.

Graphical Abstract N4-Acetylcytidine Epigenetic modification of N4-acetylcytidine (ac4C) on RNA is critical for prostate cancer progression. NAT10 enhances the proliferation and migration of prostate cancer cells by catalyzing the generation of ac4C in the mRNAs of HMGA1 and KRT8. Potentially, NAT10 will become a new target for prostate cancer diagnosis and therapy. More details can be found in article number 2310131 by Shan-Chao Zhao, Jianwen Zeng, Zhe-Sheng Chen and co-workers.

1 Introduction Prostate cancer (PCa) is an increasingly prevalent disease that has become one of the world's leading causes of cancer-related mortality for men in recent years.[1, 2] Most patients experience remission from tumor progression after androgen deprivation therapy.